Injection Instructions

GONAL-f MULTI-DOSE VIAL (450 IU, or 1050 IU) INJECTION INSTRUCTIONS

1. Necessary Materials:
   • Gonal-f multi-dose vial (powder medication)
   • Gonal-f multi-dose pre-filled 1 cc (ml) sterile water syringe with attached needle (for mixing)
   • Gonal-f multi-dose 1 cc syringe with attached needle (marked with “IU FSH” for injection)
   • Alcohol swabs
2. Inject the entire pre-filled 1 cc sterile water syringe into the Gonal-f powder vial and allow to dissolve (you may swirl bottle gently until powder dissolves completely)
3. Turn Gonal-f powder vial with dissolved medication upside down, and using the Gonal-f 1 cc syringe with attached needle (marked with “IU FSH” for injection), draw up your desired daily Gonal-f dose
4. To remove any air bubbles, point the needle up and gently tap on the syringe until all the bubbles rise to the top, then push the plunger carefully until a small drop of liquid begins to appear from the tip of the needle
5. Wipe skin with alcohol swab at intended injection site
6. Remove cap and cover off of injection needle and administer medication subcutaneously:
   • The injection can be given in the back of the arm if someone else is administering it, or in the mid-abdominal area or the top of the thigh if you are self-injecting
   • Pinch the skin with one hand and hold the syringe like a pencil with the other hand
   • Push the needle into the subcutaneous tissue at a 45-degree angle until it disappears into the skin and then inject the medication
7. Refrigerate what is left of the medication (dissolved powder vial) for your next dose
8. For your next dose (likely the next day), repeat steps 3-8 (using new injection needle)

Possible skin reaction: A red area may appear around the injection site and/or the injection site might itch and/or bruising may occur. These are all excepted reactions and will disappear over time. Please notify us if redness/bruising around the injection site appear to be enlarging or spreading.

Storage

• Unopened bottle: Maintain in room temperature.
• Opened/partially used bottle: Maintain refrigerated. Avoid freezer.

Use the disposable syringe(s) only once. Dispose of syringe(s) properly in a biohazard container. When biohazard container is full return it to our office or your pharmacy. Never leave syringes, drugs, or needles where children can reach them. Keep careful track of your prescribed dose of medication as it may change throughout the course of your treatment cycle. Whenever uncertain about your injection, contact our office for clarification.