Frozen Embryo Transfer Instructions

File: Frozen Embryo Transfer Instructions

FROZEN EMBRYO TRANSFER INSTRUCTIONS (read this once your frozen embryo transfer has been scheduled)

WHAT YOU WILL NEED IN THE 3-5 DAYS PRIOR TO, AND ON THE DAY OF FROZEN EMBRYO TRANSFER:

  1. Estrace (Estradiol) 2 mg oral tablets, or Estradiol Valerate (Delestrogen) injections (5 mg=1 cc)
    • This is a natural estrogen given to support the uterine lining, embryo implantation and the resulting pregnancy
    • It is essential to help thicken your endometrial lining to make sure it is receptive to embryos
    • It is safe to use before and after a frozen embryo transfer and in pregnancy
    • Administration begins at the onset of your frozen embryo transfer cycle (approximately 14 days prior to your embryo transfer)
    • Administration typically continues through the 9th week of gestation
    • It is not to be discontinued until otherwise specified
  2. Progesterone [progesterone in oil injections 50 mg=1 cc, or vaginal progesterone inserts (progesterone 200 mg, or Endometrin 100 mg capsules)]
    • This is given to support embryo implantation and the resulting pregnancy
    • Administration begins exactly 3 days prior to your scheduled frozen embryo transfer, or exactly 5 days prior to your scheduled frozen embryo transfer depending on whether your frozen embryos are 3 or 5 days old, respectively
    • Administration typically continues through the 9th week of gestation
    • It is not to be discontinued until otherwise specified
  3. Medrol (Methylprednisolone) 4 mg oral tablets x 16
    • This is a corticosteroid given to reduce inflammation by lightly suppressing your immune system
    • Administration begins 3 days prior to your scheduled frozen embryo transfer and continues for 4 consecutive days; in some cases, you will be required to continue 1 tablet of Medrol daily through the 6th week of gestation
    • It may cause a mild stomach upset and should be taken with food
    • Valium (Diazepam) 5 mg oral tablet
      • This is given to help relax the muscles of the uterus and to prevent cramping of the uterus during and after the embryo transfer; it also helps patients relax during the embryo transfer procedure
      • Valium is administered once just prior to the embryo transfer procedure
    • Ibuprofen (Motrin) 600 mg oral tablet
      • This medication a non-steroidal anti-inflammatory agent, which can reduce uterine contractions during embryo transfer
      • Using this medication has been shown to improve embryo implantation and pregnancy rates
      • Ibuprofen is administered once just prior to the embryo transfer procedure
    • Baby Aspirin 81 mg oral tablets
      • This is a low-dose Aspirin tablet which is used to improve blood flow to the uterus and may help with embryo implantation
      • Administration begins once you are no longer menstruating, approximately 2-3 days after estrogen treatment begins at the onset of your frozen embryo transfer cycle, and continues through the 2nd trimester of pregnancy, unless otherwise specified

SPECIFIC INSTRUCTIONS PRIOR TO AND ON THE DAY OF FROZEN EMBRYO TRANSFER

  1. If you have been taking Estrace 2 mg oral tablet three times daily — lower your dosing frequency to 2 mg twice daily (approximately 12 hours apart) on _________________________. If you have been taking Estradiol Valerate (Delestrogen) 0.5 cc (2.5 mg) injection once every 2-3 days (as instructed) — lower your dosing frequency to one 0.5 cc injection every 3 days on _________________________.
  2. If you were instructed to use progesterone in oil injections, begin with a progesterone 1 cc (50 mg/cc concentration=50 mg) intramuscular injection (see attached progesterone in oil injection instructions sheet) on _________________________, and increase the dose to a 2 cc (100 mg) on _________________________ and continue nightly until otherwise specified. If you were instructed to use progesterone vaginal inserts (200 mg progesterone capsule or 100 mg Endometrin capsule), insert the 1st vaginal capsule in the afternoon and the 2nd vaginal capsule at night before bedtime on _________________________, and then the following day on _________________________ begin administering progesterone vaginal inserts 3-times daily (morning, afternoon, and night), until otherwise specified.
  3. Medrol 4 mg tablets x 4 pills (together) daily x 4 days to be started on _________________________ (3 days prior to your scheduled frozen embryo transfer).
  4. Valium 5 mg pill — take one pill approximately 45 minutes prior to your scheduled frozen embryo transfer time.
  5. Ibuprofen 600 mg pill — take one pill approximately 45 minutes prior to your scheduled embryo transfer time.

SPECIFIC INSTRUCTIONS PRIOR TO AND ON THE DAY OF FROZEN EMBRYO TRANSFER (CONT’D)

  1. Baby Aspirin 81 mg tablets — continue taking 1 tablet of baby Aspirin daily, as you have been doing, until otherwise specified.
  2. Your frozen embryo transfer procedure is scheduled for _________________________ am/pm. Please report to In Vitrotech Labs, Inc. (9201 W. Sunset Blvd, Suite 202, West Hollywood, CA 90069, tel 310-550-1951) with your partner or an accompanying adult no later than 45 minutes prior to your scheduled procedure. Please make sure you arrive with your bladder full (make sure you drink enough water to fill your bladder moderately; do not empty your bladder prior to the embryo transfer procedure unless otherwise specified). You and your partner should avoid wearing any scented lotions, perfumes, colognes... as these may affect eggs, sperm and embryos in the IVF laboratory. Your partner or an accompanying adult must drive you home after the procedure as you will not be able to drive yourself.
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Eliran Mor, MD • Encino, Santa Monica, Valencia & West Hollywood, CA

Reproductive Endocrinologist located in Encino, Santa Monica, Valencia & West Hollywood, CA • Irene Woo, MD

Doctor Mor received his medical degree from Tel Aviv University-Sackler School of Medicine in Israel. He completed a four-year residency in Obstetrics and Gynecology at New York Methodist Hospital in Brooklyn, New York. Subsequently, Dr. Mor completed a three-year fellowship in Reproductive Endocrinology and Infertility at the University of Southern California. Doctor Mor is Board Certified in both Reproductive Endocrinology/Infertility and Obstetrics and Gynecology. Throughout his career Dr. Mor has researched many topics in infertility and human reproduction, including polycystic ovary syndrome (PCOS); emergency contraception; neuroendocrinology; insulin resistance; male factor infertility; donor sperm insemination; tubal factor infertility; IVF stimulation protocols; congenital uterine anomalies; tubal gamete/embryo transfer (GIFT/ZIFT/TET); pregnancy at advanced reproductive age; and hormone replacement therapy (HRT), and continues to do so today. He is a member, in excellent standing, of multiple prestigious medical societies, including the American Society of Reproductive Medicine (ASRM), the Pacific Coast Reproductive Society (PCRS), the Society of Laparoendoscopic Surgeons (SLS), and the American College of Obstetricians and Gynecologists (ACOG), and remains a Clinical Instructor at USC.

Doctor Mor is one fertility expert who is constantly striving to stay on the cutting-edge of fertility treatments and human reproduction. In addition to monthly Journal Club meetings/publication review sessions and educational seminars/lectures, Dr. Mor attends at least two major Reproductive Endocrinology/Infertility meetings each year in an effort to present his patients with the latest in innovative reproductive care. Only interventions that have been tested and validated through multiple good studies are adopted in Dr. Mor’s practice, in an effort to administer safe and effective treatments to achieve a healthy pregnancy.

A true “patients’ doctor,” Dr. Mor is and will be your physician throughout your fertility journey! All consultations, after-hour inquiries, pelvic examinations, ultrasound examinations, diagnostic procedures, assisted reproductive procedures (egg retrievals, embryo transfers...), and surgical procedures, if needed, will be performed by Dr. Mor. Involvement in every aspect of your fertility care and complete micromanagement of your treatment makes Dr. Mor your ideal partner in your path to becoming pregnant.

See Dr. Mor's Publications

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California Center for Reproductive Health

Doctor Mor received his medical degree from Tel Aviv University-Sackler School of Medicine in Israel. He completed a four-year residency in Obstetrics and Gynecology at New York Methodist Hospital in Brooklyn, New York. Subsequently, Dr. Mor completed a three-year fellowship in Reproductive Endocrinology and Infertility at the University of Southern California. Doctor Mor is Board Certified in both Reproductive Endocrinology/Infertility and Obstetrics and Gynecology. Throughout his career Dr. Mor has researched many topics in infertility and human reproduction, including polycystic ovary syndrome (PCOS); emergency contraception; neuroendocrinology; insulin resistance; male factor infertility; donor sperm insemination; tubal factor infertility; IVF stimulation protocols; congenital uterine anomalies; tubal gamete/embryo transfer (GIFT/ZIFT/TET); pregnancy at advanced reproductive age; and hormone replacement therapy (HRT), and continues to do so today. He is a member, in excellent standing, of multiple prestigious medical societies, including the American Society of Reproductive Medicine (ASRM), the Pacific Coast Reproductive Society (PCRS), the Society of Laparoendoscopic Surgeons (SLS), and the American College of Obstetricians and Gynecologists (ACOG), and remains a Clinical Instructor at USC.

Doctor Mor is one fertility expert who is constantly striving to stay on the cutting-edge of fertility treatments and human reproduction. In addition to monthly Journal Club meetings/publication review sessions and educational seminars/lectures, Dr. Mor attends at least two major Reproductive Endocrinology/Infertility meetings each year in an effort to present his patients with the latest in innovative reproductive care. Only interventions that have been tested and validated through multiple good studies are adopted in Dr. Mor’s practice, in an effort to administer safe and effective treatments to achieve a healthy pregnancy.

A true “patients’ doctor,” Dr. Mor is and will be your physician throughout your fertility journey! All consultations, after-hour inquiries, pelvic examinations, ultrasound examinations, diagnostic procedures, assisted reproductive procedures (egg retrievals, embryo transfers...), and surgical procedures, if needed, will be performed by Dr. Mor. Involvement in every aspect of your fertility care and complete micromanagement of your treatment makes Dr. Mor your ideal partner in your path to becoming pregnant.

See Dr. Mor's Publications


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We invite you to join our family as we look to expand yours!

Doctor Mor is a Board Certified Reproductive Endocrinology/Infertility expert with extensive experience in the most advanced fertility treatments available. Under his leadership, CCRH has become renowned for superior reproductive care, receiving rave reviews year after year. The Center is a boutique practice with exceptionally personalized service, customized and individually-tailored to each person or couple's needs with unmatched results.

Great emphasis is placed on proper testing and accurate
diagnosis, allowing for safe and effective treatments to achieve the ultimate outcome – a healthy baby!

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Professional Affiliations/Resources

The physicians and staff of the California Center for Reproductive Health are dedicated to patient education and care. The Center is affiliated with several prestigious medical societies and organizations aimed at educating both healthcare professionals and patients and at improving patient care. The following is a list of professional affiliations:

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